Proceedings of the SCSK Conference (대한화장품학회:학술대회논문집)
- 2003.09a
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- Pages.291-312
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- 2003
Antioxidant Activity of Cercis chinensis and Its Protective Effect on Skin Aging
- Na, Min-Kyun (Jakwang Research Institute, Hansaeng Cosmetics Co., Ltd.) ;
- Bae, Ki-Hwan (College of Pharmacy, Chungnam National University) ;
- Hong, Nam-Doo (Jakwang Research Institute, Hansaeng Cosmetics Co., Ltd) ;
- Yoo, Jae-Kuk (Jakwang Research Institute, Hansaeng Cosmetics Co., Ltd) ;
- Nobuhiko Miwa (Department of Biotechnology, Hiroshima Prefectural University School of BioSciences)
- Published : 2003.09.01
Abstract
Reactive oxygen species are capable of damaging biomolecules such as lipids, proteins, and DNA, which can not only lead to various diseases, but also oxidative damage resulting aging. In our previous study, Cercis chinensis (Leguminosae) showed a potent antioxidant activity. Nineteen compounds were isolated through antioxidant activity-guided fractionation. The C. chinensis extract and some of the constituents exhibited a potent antioxidant activity on the free radicals and lipid peroxidation and a notable protective effect on the t-BuOOH induced oxidative damage. In vivo test of skin damage induced by UVB irradiation, the extract of C. chinensis and a constituent, piceatannol, exhibited a significant protective effect. The life-span of the HEK-N/F cells were extended by 1.21-2.12 fold as a result of the continuous administration of 3