Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)
- 2003.06a
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- Pages.72-72
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- 2003
Crystal Structure of PAS factor from Vibrio vulnificus
- Lee, Jun-Hyuck (Department of Life Science, Kwangju Institute of Science & Technology) ;
- Park, Seong-Hwan (Department of Life Science, Kwangju Institute of Science & Technology) ;
- Im, Young-Jun (Department of Life Science, Kwangju Institute of Science & Technology) ;
- Kim, Mun-Kyoung (Department of Life Science, Kwangju Institute of Science & Technology) ;
- Kang, Gil-Bu (Department of Life Science, Kwangju Institute of Science & Technology) ;
- Kim, Young-Ran (Department of Microbiology, Chonnam National University Medical School) ;
-
Rhee, Joon-Haeng
(Department of Microbiology, Chonnam National University Medical School)
;
- Eom, Soo-Hyun (Department of Life Science, Kwangju Institute of Science & Technology)
- Published : 2003.06.01
Abstract
The PAS factor, whose gene has been cloned from V vulnifcus, is a protein secretion factor. Although the role of the PAS factor in Vibrio is still unknown, it may be involved with the bacterial protein secretion. The PAS factor is a 76 amino acid polypeptide, and its expression in E. coli cells makes the host cell membrane leaky, resulting in the excretion of periplasmic proteins into the culture medium. Highly expressed PAS factor is harmful to the cell, this may be due to a disruption of the membrane structure or function.
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