Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Crystallization and preliminary X-ray crystallographic analysis of Quinolinate phosphoribosyltransferase of Helicobacter pylori

  • Kim, Mun-Kyoung (Dept. of Life Science, Kwangju Institute of Science & Technology) ;
  • Kim, Yun-Sik (Dept. of Life Science, Kwangju Institute of Science & Technology) ;
  • Park, Seong-Hwan (Dept. of Life Science, Kwangju Institute of Science & Technology) ;
  • Im, Young-Jun (Dept. of Life Science, Kwangju Institute of Science & Technology) ;
  • Eom, Soo-Hyun (Dept. of Life Science, Kwangju Institute of Science & Technology)
  • Published : 2003.06.01
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Abstract

The quinolinic acid(QA) phosphoribosyltransferase (PRTase) (EC 2.4.2.19), is a key enzyme involved in NAD$\^$+/ biosynthesis in prokaryotes and eukaryotes, The QAPRTase produces nicotinic acid mononucleotide (NAMN) from QA and 5-phosphoribosyl-1-pyrophosphate (PRPP). For this reaction, the QA is decarboxylated (Fig.1). Produced NAMN is used to a synthesis of nicotinate adenine dinucleotide(NAD$\^$+/).

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