Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)
- 2003.06a
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- Pages.69-69
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- 2003
NMR structural studies on Human CD99 Type I
- Kim, Hai-Young (Dept. of Biochemistry and HTSD-NMR National Research Laboratory, Yonsei University) ;
- Kim, Young-Mee (Dept. of Biochemistry and HTSD-NMR National Research Laboratory, Yonsei University) ;
- Joon Shin (Dept. of Biochemistry and HTSD-NMR National Research Laboratory, Yonsei University) ;
- Shin, Young-Kee (Dept. of Pathology, College of Medicine, Seoul National University) ;
- Park, Seong-Hoe (Dept. of Pathology, College of Medicine, Seoul National University) ;
- Lee, Weontae (Dept. of Biochemistry and HTSD-NMR National Research Laboratory, Yonsei University)
- Published : 2003.06.01
Abstract
Human CD99 is a ubiquitous 32-kDa transmembrane protein encoded by the mic2 gene. The major cellular functions of CD99 protein are related to homotypic cell adhension, apoptosis, vesicular protein transport, and differentiation of thymocytes or T cells. Recently it has been reported that expression of a splice variant of CD99 transmembrane protein (Type I and Type II) increases invasive ability of human breast cancer cells. To understand structural basis for cellular functions of CD99 (Type I), we have initiated studies on hCD99
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