Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)
- 2003.06a
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- Pages.40-40
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- 2003
Combinatorial modulation of the spontaneous firings by glutamate receptors in dopamine neurons of the rat substantia nigra pars compacta
- Kim, Shin-Hye (Department of Physiology, Sungkyunkwan University School of Medicine) ;
- Park, Yu-Mi (Department of Physiology, Sungkyunkwan University School of Medicine) ;
- Sungkwon Chung (Department of Physiology, Sungkyunkwan University School of Medicine) ;
- Uhm, Dae-Yong (Department of Physiology, Sungkyunkwan University School of Medicine) ;
- Park, Myoung-Kyu (Department of Physiology, Sungkyunkwan University School of Medicine)
- Published : 2003.06.01
Abstract
Spontaneous firing rate and patterns of dopaminergic neurons in midbrain are key factors in determining the level of dopamine at target loci as well as in the mechanisms such as reward and motor coordination. Although glutamate, as a major afferent, is reported to enhance firing rate, the detailed actions of NMDA-, AMPA/kainate-, and metabotropic glutamate receptors (mGluR) on filing patterns are not clear. Thus we have investigated the role of glutamate receptors on the spontaneous firing activities using the network-free, acutely isolated dopamine neurons from substantia nigra pars compacta(SNc) of the 9-14 days rat. The isolated cells showed spontaneous regular firings of near 2.5 Hz, whose rate was enhanced by glutamate at submicromolar levels (0.3
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