Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)
- 2003.06a
- /
- Pages.28-28
- /
- 2003
Structural Basis of the Disease-related Proteins: Target Oriented Structural Proteomics
- Hwang, Kwang-Yeon (CrystalGenomics, Inc. Daeduk BioCommunity) ;
- Lee, Tae-Gyu (CrystalGenomics, Inc. Daeduk BioCommunity) ;
- Kim, Jin-Hwan (CrystalGenomics, Inc. Daeduk BioCommunity) ;
- Jeon, Young-Ho (CrystalGenomics, Inc. Daeduk BioCommunity) ;
- Seonggu Ro (CrystalGenomics, Inc. Daeduk BioCommunity) ;
- Cho, Joong-Myung (CrystalGenomics, Inc. Daeduk BioCommunity)
- Published : 2003.06.01
Abstract
To discover new drugs more quickly and more efficiently, pharmaceutical companies and biotechnology firms are increasingly turning to the genomics and the structural proteomics technologies. Structural-proteomics can provide a foundation for this through the determination and analysis for protein structure on a genomics scale. Among many structures determined by CGI, we will present with the representative examples drawn from our work on novel structures or complex structures of the disease-related proteins. The alpha subunit of Hypoxia-inducible factor (HIF) is targeted for degradation under normoxic conditions by an ubiquitin-ligase complex that recognizes a hydroxylated proline residue in HIF, Hydroxylation is catalysed by HIF prolyl 4-hydroxylases (HIFPH) which are Fe(II) and 2-oxoglutarate (2-OG) dependent oxygenases. Here, we discuss the first crystal structure of the catalytic domain of HIFPH in complexes, with the Fe(II)/2-OG at 1.8
Keywords