Actin filaments in synaptic transmission and synaptogenesis

Actin filament is a major cytoskeleton in synapses and highly enriched in the presynaptic and postsynaptic compartments. Their roles in synaptic vesicle recycling and synaptogenesis have been extensively studied but functional evidence whether actin filaments are involved in these processes is as yet lacking. Dysfunction in synaptic vesicle recycling causes various diseases such as Alzheimer's disease, Schizophrenia, Bipolar disease, depression etc.