한국환경독성학회:학술대회논문집 (Proceedings of the Korea Society of Environmental Toocicology Conference)
- 한국환경독성학회 2003년도 춘계학술대회
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- Pages.192-192
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- 2003
Estrogenic activity of Pomegranate extract in MCF7-ERE cells
- Cho minjungo (Department of Pharmacy, Ewha womans University) ;
- An Jinyoung (Department of Pharmacy, Ewha womans University) ;
- Lansky Ephraim (Department of Pharmacy, Ewha womans University)
- 발행 : 2003.05.01
초록
Pomegranate, a small tree originating in Orient, belongs to Punicaceae family. The seeds contain an oil of which about 80% is rare trans 18 carbon fatty acid (punicic acid), and have highest botanical concentration of a sex steroid, estrone. Pharmacological properties of pomegranate extract have been studied, with anti-microbial, anti-parasitic, ant-viral, and anti-cancer effects. We have examined the estrogenic activity of the pomegranate extracts using MCP-7-ERE cells. MCF-7-ERE cells, stably transfected with pERE-Luc were treated various amount of pomegranate extract and after overnight treatments, luciferase activity were measured. Estradiol(E2) dose dependently induced luciferase activity in this cell and maximal response is obtained at 100pM E2.
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