Proceedings of the KACD Conference (대한치과보존학회:학술대회논문집)
- 2003.11a
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- Pages.583-583
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- 2003
The effect of substance P on the secretion of interleukin-8 and MCP(Monocyte Chemoattractant Protein)-1 from human dental pulp tissues
- Shin, Han-Ju (Department of Conservative Dentistry, College of Dentistry, Kyung-Hee University) ;
- Choi, Gi-Woon (Department of Conservative Dentistry, College of Dentistry, Kyung-Hee University) ;
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Park, Sang-Jin
(Department of Conservative Dentistry, College of Dentistry, Kyung-Hee University)
- Published : 2003.11.01
Abstract
Recent study reported whether the cultured human pulp cells increase IL-8 secretion in response to SP stimulation22). In the present study, whether induction of IL-8 or MCP-1 in pulp tissue can be detected using enzyme-linked immunosorbent assay(ELISA) with ex vivo pulpal explants exposed to neuropeptides in culture and the IL-8 expression using immunohistochemical analysis with the ex vivo pulpal explants exposed to neuropeptides was evaluated. To investigate further mechanisms that may contribute to leukocyte recruitment in lesions of endodontic origin, the differential expression of IL-8 and MCP-1 by human dental pulp tissues stimulated in vitro by the Substance P was examined.(omitted)
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