The effects of proinflammatory cytokines on mineralization and HO-1 expression in human pulp cells

  • Kwon, Young-Yim (Department of Conservative Dentistry, College of Dentistry, Wonkwang University) ;
  • Kim, Eun-Chul (Department of Conservative Dentistry, College of Dentistry, Wonkwang University)
  • Published : 2003.11.01

Abstract

IL-1${\alpha}$ and TNF-${\alpha}$ play an important role in initiating and coordinating the cellular events that make up the immune response to infection. The purpose of this study was to examine the effects of proinflammatory cytokines on mineralization and HO-1 protein expression in the human pulp cells. Human pulp cell cultures between the fifth and sixth passage were used in this study. Alkaline phosphatase and osteonectin were selected as markers for mineralization that is, odontoblast-like differentiation.(omitted)

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