한국응용약물학회:학술대회논문집 (Proceedings of the Korean Society of Applied Pharmacology)
- 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
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- Pages.115-115
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- 2003
Asymmetric Total Synthesis of the Glycosidase Inhibitor, 1,4-dideoxy-l,4-imino-D-arabinitol(DAB1)
- Kim, In-Su (College of Pharmacy, Sungkyunkwan University) ;
- Hoon, Jung-Young (College of Pharmacy, Sungkyunkwan University)
- 발행 : 2003.11.01
초록
Naturally occurring sugar mimics with a nitrogen in the ring are classified into five structural classes: polyhydroxylated pyrrolidines, piperidines, indolizidines. pyrrolizidine, and nortropanes. Glycosidase are involved in a wide range of important biological processes, such as intestinal digestion, post-translational processing of glycoproteins and the lysosomal catabolism of glycoconjugate. The realization that alkaloidal sugar mimics might have enormous therapeutic potential in many diseases such as viral infection, cancer and diabetes has led to increasing interest and demand for these compounds. Most of these effects can be shown to result from the direct or indrect inhibition of glycosidases.
키워드