한국환경성돌연변이발암원학회:학술대회논문집 (Proceedings of the Korea Environmental Mutagen Society Conference)
- 한국환경성돌연변이발암원학회 2002년도 Molecular and Cellular Response to Toxic Substances
- /
- Pages.80-88
- /
- 2002
Interactions between Collagen IV and Collagen-Binding Integrins in Renal Cell Repair after Sublethal Injury
- Nony, Paul A, (Department of Pharmacology and Toxicology, University of Arkansas for Medical Science) ;
- Schnellmann, Rick G. (Department of Pharmacology and Toxicology, University of Arkansas for Medical Science)
- 발행 : 2002.11.08
초록
Recent studies demonstrate that collagen IV selectively pro-motes the repair of physiological processes in sublethally injured renal proximal tubular ceils (RPTC). We sought to further define the mechanisms of cell repair by measuring the effects of toxicant injury and stimulation of repair by L-ascorbic acid-2-phosphate (AscP), exogenous collagen IV, or function-stimulating integrin antibodies on the expression and subcellular localization of collagen-binding integrins (CBI) in RPTC. Expression of CBI subunits
키워드
- ECM;
- extracellular matrix;
- RPTC;
- renal poximal tubular cells;
- BM;
- basement membrane;
- DCVC;
- S-(1,2-dichlorovinyl)-L-cysteine;
- Ascp;
- L-ascorbic acid-2-phosphate;
- CBI;
- collagen-binding integrins;
- FITC;
- fluorescein isothiocynate;
- BSA;
- bovine serum albumin;
- PBS;
- phosphate-buffered saline;
- ERK;
- extracellular-signal regulated kinase;