Proceedings of the Microbiological Society of Korea Conference (한국미생물학회:학술대회논문집)
- 2002.10a
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- Pages.162-172
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- 2002
Mad1p, a Component of the Spindle Assembly Checkpoint in Fission Yeast, Suppresses a Novel Septation-defective Mutant, sun1, in a Cell Division Cycle
- Kim In G. (Department of Molecular biology, Graduate school of biotechnology, Korea University) ;
- Rhee Dong K. (Department of Molecular biology, Graduate school of biotechnology, Korea University) ;
- Jeong Jae W. (Department of Molecular biology, Graduate school of biotechnology, Korea University) ;
- Kim Seong C. (Department of Molecular biology, Graduate school of biotechnology, Korea University) ;
- Won Mi S. (Genome Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
- Song Ki W. (Department of Biochemistry, Yonsei University) ;
- Kim Hyong B. (Department of Molecular biology, Graduate school of biotechnology, Korea University)
- Published : 2002.10.01
Abstract
Schizosaccharomyces pombe is suited for the study of cytokinesis as it divides by forming a septum in the middle of the cell at the end of mitosis. To enhance our understanding of the cytokinesis, we have carried out a genetic screen for temperature-sensitive S. pombe mutants that show defects in septum formation and cell division. Here we present the isolation and characterization of a new temperature-sensitive mutant, sun1(septum uncontrolled), which undergoes uncontrolled septation during cell division cycle at restrictive temperature