Proceedings of the Microbiological Society of Korea Conference (한국미생물학회:학술대회논문집)
- 2002.10a
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- Pages.40-50
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- 2002
Multi-host Pathogenesis by Pseudomonas aeruginosa and Use of Drosophila melanogaster as a New Model Host
- Cho You-Hee (Department of Life Science, Sogang University) ;
- Lau Gee (Department of Surgery, Harvard Medical School, Massachusetts General Hospital and Shriner's Burns Hospital) ;
- Rahme Laurence (Department of Surgery, Harvard Medical School, Massachusetts General Hospital and Shriner's Burns Hospital)
- Published : 2002.10.01
Abstract
Fruit fly, Drosophila melanogaster has developed efficient immune mechanisms to prevent microbial infection, which are consisted of cellular and humoral responses. During the systemic or local infection, two distinct pathways (Toll and Imd) play major roles in antimicrobial peptide synthesis. The Toll pathway is required to defend Gram-positive bacterial and fungal infections, whereas the Imd pathway is important in Gram-negative bacterial infection. We have shown that the infection of the opportunistic Gram-negative bacterium, Pseudomonas aeruginosa strain PA14 (PA14) into fly dorsal thorax can kill the flies within 48 h (
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