Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Examination of alginate/PEl/DNA polyplex as a gene delivery system: enhancing transfection efficiency in the presence of serum and reducing cytotoxicity

  • Jiang, Ge (Korea Research Institute of Bioscience and Biotechnology) ;
  • Min, Sang (Korea Research Institute of Bioscience and Biotechnolog) ;
  • Kim, Mi-Na (Korea Research Institute of Bioscience and Biotechnolog) ;
  • Lim, Mi-Jung (Korea Research Institute of Bioscience and Biotechnolog) ;
  • Yeom, Young-Il (Korea Research Institute of Bioscience and Biotechnology)
  • Published : 2002.10.01
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Abstract

Synthetic vectors have been considered as a safer and more versatile alternative to viral-based gene delivery systems. A variety of simple synthetic vector systems such as cationic lipid- and polymer-complexed plasmid DNA were shown to have a significant transfection activity in vitro but their use in vivo has been hampered by the decrease in transfection efficiency mediated by non-specific electrostatic interactions with serum components. (omitted)

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