Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.427.1-427.1
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- 2002
Cationic Emulsions with Galactosylated Chitosan as a Novel Gene Delivery System
- Choi, Woo-Jeong (College of pharmacy, Seoul national University) ;
- Choi, Sung-Hee (College of pharmacy, Seoul national University) ;
- Ahn, Woong-Shick (College of Medicine, the Catholic University of Kore) ;
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Kim, Chong-Kook
(College of pharmacy, Seoul national University)
- Published : 2002.10.01
Abstract
To improve stability and transfection efficiency, a novel combination of cationic emulsion and galactosylated chitosan was developed for targeted gene delivery. Six formulations of cationic liposome and our novel emulsion were prepared for comparison of stability and transfection efficiency. Cationic liposomes composed of 3［N-(N.N dimethylaminoethylene) carbamoyl］ cholesterol (DC-Chol) and dioleyl phophatidyl ethanolamine (DOPE) were prepared by extrusion method and cationic emulsions composed of DC-Chol. DOPE. castor oil, and Tween 80 were prepared by sonication method. (omitted)
Keywords