대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.425.2-425.2
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- 2002
Thermo-sensitive lipid nanoparticles as a novel topical delivery system of retinol
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Jee, Jun-Pil
(College of Pharmacy. Seoul National University)
;
- Lee, Mi-Kyung (College of Pharmacy. Seoul National University) ;
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Kim, Chong-Kook
(College of Pharmacy. Seoul National University)
- 발행 : 2002.10.01
초록
The purpose of this study was to prepare thermo-sensitive solid-lipid nanoparticles (SLNs) with a lipid melted at human body temperature and to evaluate physicochemical properties of SLNs containing retinol. anti-wrinkle agent. as a model drug. SLNs were prepared using a high pressure homogenizing method. The SLNs were composed of retinol as a model drug. thermo-sensitive lipid (DS-CBS) as a lipid core. and egg phosphatidylcholine and Tween 80 as surfactants. Manufacturing variables such as homogenization pressure. (omitted)
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