Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.418.3-419
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- 2002
Determination of enalapril in human blood by high-performance liquid chromatography mass spectrometer.
- Chang, Dong-Jin (Department of Pharmaceutics. College of Pharmacy. Seoul National University) ;
- Shim, Chang-Koo (Department of Pharmaceutics. College of Pharmacy. Seoul National University) ;
- Chung, Suk-Jae (Department of Pharmaceutics. College of Pharmacy. Seoul National University)
- Published : 2002.10.01
Abstract
Enalapril. a prodrug. is the ethyl ester of a long-acting angiotensin converting enzyme inhibitor. enalaprilat. Because enalapril does not contain any appreciable chromophore. detection of the drug in a complex matrix (e.g.. biological fluids) has been problematic with conventional detection systems in high-performance liquid chromatography (HPLC). As a result. determination of enalaprillevel in blood samples has been typically carried out using HPLC-MS/MS in the literature. (omitted)
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