Transfersomes-mediated gene transfer into organs in mice by direct application on intact skin

  • Lee, Eun (Seoul National University. College of Pharmacy) ;
  • Kim, Adele (Seoul National University. College of Pharmac) ;
  • Kim, Chong-Kook (Seoul National University. College of Pharmacy)
  • 발행 : 2002.10.01

초록

Transfersomes are highly detormable hydrophilic lipid vesicles that are able to penetrate the skin barrier so that they can be used to carry low- and high-molecular weight molecules into the body. Until recently. it has been reported that molecules such as insulin. interleukin-2 and several other large molecules have been transported into the body using Transfersomes as a delivery system. Here however, for the very first time, genes (GFP) have been transported into the mice non-invasively using the Transtersomes as a delivery vehicle. (omitted)

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