대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
- /
- Pages.413.2-413.2
- /
- 2002
Pharmacokinetics of New Solubilizer in Intravenous Micelle Formulation of Paclitaxel in Mice
- Lee, Sun-A (College of Pharmacy, Ewha Womans University) ;
- Han, Kyu-Won (College of Pharmacy, Ewha Womans University) ;
- Um, So-Young (College of Pharmacy, Ewha Womans University) ;
- Kim, Kil-Soo (College of Pharmacy, Ewha Womans University)
- 발행 : 2002.10.01
초록
Paclitaxel is an antitumor agent with poor water solubility and its pharmacokinetics are nonlinear. Cremophor EL. a surfactant used in the formulation of paclitaxel. may cause adverse effects. New solubilizer(Aceporol 460) was developed to reduce side effects of Cremophor EL and to increase the effect of drug as surfactant used in the intravenous micelle formulation of anticancer drug paclitaxel. We studied easy, rapid quantitative determination of Aceporol 460 in mouse plasma samples. which was achieved by complexation of the compound with the Coomassie brilliant blue G-250 dye in protein-free extracts. (omitted)
키워드