대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.412.1-412.1
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- 2002
Preparation and release characteristics of PVP-based solid dispersion capsules containing solubilizers
- Cao, Qing-Ri (Biological Rhythm and Controlled Release Lab., College of Pharmacy, Kangwon National University) ;
- Kim, Tae-Wan (Pharm Tech Research Incorp) ;
- Choi, Choon-Young (Pharm Tech Research Incorp) ;
- Lee, Beom-Jin (Pharm Tech Research Incorp.)
- 발행 : 2002.10.01
초록
Purpose. To prepare PVP-based solid dispersions containing lovastatin (LOS) and solubilizers (sodium lauryl sulfate. Tween80. oleic acid) to enhance dissolution of practically insoluble LOS. Methods. Solid dispersions containing LOS were prepared by dissolving two different organic solvent systems (acetone/ethanol or acetonitrile/ethanol). Results. The stickiness and flowability of solid dispersion powders were dependent on the composition and ratio of the solubilizers. (omitted)
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