Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.407.2-407.2
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- 2002
Chemiluminogenic imaging for highly sensitive detection of DNA
- Kai, Masaaki (School of Pharmaceutical Sciences, Nagasaki University) ;
- Hirayama, Fumiko (School of Pharmaceutical Sciences, Nagasaki Universi) ;
- Ohta, Kazuko (School of Pharmaceutical Sciences, Nagasaki Universi) ;
- Kabashima, Tsutomu (School of Pharmaceutical Sciences, Nagasaki Universi) ;
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Lee, Myung-Koo
(College of Pharmacy, Chungbuk National University)
- Published : 2002.10.01
Abstract
We have been studing sensitive non-enzymatic chemiluminescence (CL) imaging methods for the detection of DNA. For one of our methods, a unique chemical derivatization reagent. 3'. 4', 5'-trimethoxyphenylglyoxal (TMPG) was utilized. This reagent reacted specifically with guanine bases in nucleic acids to quickly produce a chemiluminescent derivative under mild reaction conditions. (omitted)
Keywords