대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.396.3-397
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- 2002
Chiral Separation of Non-Steroidal Inflarnrnatory Drugs and Metabolites by Achiral Gas Chromatography as O- Trifluoroacetylated (－ )-Menthyl Esters
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Lee, Yoon-Suk
(College of Pharmacy Sungkyunkwan University)
;
- Paik, Man-Jeong (Kyonggi Pharmaceutical Research Cente) ;
- Kim, Kyoung-Rae (Kyonggi Pharmaceutical Research Center)
- 발행 : 2002.10.01
초록
Because of the differences in biological and pharmacological properties between enantiomers of chiral acidic non-steroidal antiinflammatory drugs (NSAIDs) in human body. accurate determinations of their optical purities have been in great need. Racemic ibuprofen. tiaprofen. suprofen. flubiprofen and napoxen were reacted with (1R. 28. 5R)-(－)-menthol to convert them to corresponding diastereomeric (1R. 2S. 5R)-(－ )-menthyl esters. (omitted)
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