대한약학회:학술대회논문집 (Proceedings of the PSK Conference)

대한약학회 (The Pharmaceutical Society of Korea)
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Studies on the Analysis of Anti-impotent Drugs(II) - Rapid analysis of Sildenafil and modified Sildenafils using HPTLC

  • Choi, Hyun-Cheol (Drug Evaluation in Korea Food ＆ Drug Administration) ;
  • Kang, Sin-Jung (Drug Evaluation in Korea Food ＆ Drug Administratio) ;
  • Yun, Mi-Ok (Drug Evaluation in Korea Food ＆ Drug Administratio) ;
  • Park, Sang-Aeh (Drug Evaluation in Korea Food ＆ Drug Administratio) ;
  • Kim, Ho-Jeong (Drug Evaluation in Korea Food ＆ Drug Administratio) ;
  • We, Sae-Seung (Drug Evaluation in Korea Food ＆ Drug Administration)
  • 발행 : 2002.10.01
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초록

HPTLC(High Performance Thin Layer Choromatography) method was developed for rapid and precise analysis of Sildenafil and modified Sildenafils(Vardenafil. Homosildenafil, Tadanafil). Chromatographic conditions were Optimized for simultaneous analysis of them and each specific UV spectra were obtained. The calibration curve of Sildenafil and modified Sildenafils had a linearity in the range of 1.0 ~ 56.5 $\mu$/ml at 254nm. The Limit of Detection(LOD) and the limit of Quantification(LOQ) of Sildenafil and modified Sildenafils were 0.8$\mu$/ml and 1.0$\mu$g/ml. (omitted)

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