대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.395.1-395.1
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- 2002
Development of economic preparative method of (S)-(＋)-enantiomer of arylpropionic acids
- Lee, Jae (College of Pharmacy Kangwon National University) ;
- Shin, Dae (College of Pharmacy Kangwon National University) ;
- Seo, Sang (Yuhan Coporatio) ;
- Kang, Jong-Seong (ChungNam National University) ;
- Kim, Kyeong (College of Pharmacy Kangwon National University)
- 발행 : 2002.10.01
초록
Many of the chiral NSAIDs are marketed as racemates. There is an increasing interest in developing the enantiomerically pure forms of the NSAIDs because the anti-inflammatory activity of NSAIDs have previously been shown to be largely sterospecific for the (S)-(＋)-enantiomer. Therefore, simple and economic preparative method to identify the (S)-(＋)-enantiomer of NSAIDs (aryl propionic acids) as diastereomeric solvation complex was developed using several chiral solvating agents by recrystallization of racemate and solvent fractionation. (omitted)
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