Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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A specific butyrylcholinesterase inhibitor from the fruits of Evodia officinalis

  • Kim, Young-Sup (Korea Research Institute of Chemical Technology) ;
  • Kim, Jeoung-Seob (Department of Chemical Technology Hanbat National University) ;
  • Kim, Seong-Kie (Department of Chemical Technology Hanbat National University) ;
  • Heor, Jung-Hee (Department of Chemical Technology Hanbat National University) ;
  • Lee, Woo-Lak (Department of Chemical Technology Hanbat National University) ;
  • Lee, Bong-Ho (Department of Chemical Technology Hanbat National University) ;
  • Choi, Byuoung-Wook (Department of Chemical Technology Hanbat National University) ;
  • Ryu, Geon-Seek (Department of Chemical Technology Hanbat National University) ;
  • Park, Eun-Kyung (Department of Chemical Technology Hanbat National University) ;
  • Ryu, Shi-Yong (Department of Chemical Technology Hanbat National University)
  • Published : 2002.10.01
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Abstract

Neuroscience and molecular biology studies show that inappropriate butyrylcholinesterase (BuChE) activity as well as acetylcholinesterase (AChE) activity increases the risk and/or progression of Alzheimer's disease. BuChE may also regarded to participate in the transformation of Abeta (${\beta}$-amyloid) from an initially benign form to an eventually malignant form associated with neuritic tissue degeneration and clinical dementia. (omitted)

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