Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Butyrylcholineesterase(BChE) Inhibitors from a Brown Alga Sargassum sp.

  • Park, Soo-Hee (Dep. of Chemical Technology, Hanbat National University) ;
  • Ryu, Geon-Seek (Dep. of Chemical Technology, Cheju National University) ;
  • Choi, Byoung-Wook (Dep. of Chemical Technology, Cheju National University) ;
  • Lee, Bong-Ho (Dep. of Chemical Technology, Cheju National University)
  • Published : 2002.10.01
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Abstract

In continuing search for BChE-inhibitory compounds from Korean marine algae. we found a highly potent inhibitory activity in the methanolic extract of Sargassum species. After partition of the MeOH extract between $CHCl_3$ and 30% MeOH. the former layer was subjected to a series of ODS flash chromatography. silica column chromatography. and preparative TLC to afford three compounds (1-3). Detailed structural elucidation of them is in progress. Compound 1 showed potent BChE-inhibitory activity with $IC_{50}$ values of 11 ng/mL. (omitted)

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