대한약학회:학술대회논문집 (Proceedings of the PSK Conference)

대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Isolation and Structure Determination of Cytotoxic Compounds with Topoisomerse I and II Inhibitory Activity from the spikes of Prunella vulgaris var. lilaeina

  • Byun, S.J. (College of Pharmacy, Catholic University of Daegu) ;
  • Lee, J.E. (College of Pharmacy, Catholic University of Daeg) ;
  • Son, J.K. (College of Pharmacy, Yeungnam University) ;
  • Lee, J.S. (Department of Biochemistry College of Science, Yeungnam University) ;
  • Lee, S.H. (College of Pharmacy, Yeungnam University) ;
  • Park, Y.S. (College of Pharmacy, Catholic University of Daeg) ;
  • Woo, M.H. (College of Pharmacy, Catholic University of Daegu)
  • 발행 : 2002.10.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Prunella vulgaris var. lilacina (Labiatae) has been used as a Korean traditional medicine for the treatment of. fever. inflammation. urinary disadvantage and cancer. We previously isolated three $\alpha$-amyrin triterpenoids from n-butanol-I extract. They are 3$\alpha$-hydroxyurs-12-ene-28-oic acid (ursolic acid). 2$\alpha$, 3$\alpha$-dihydroxyurs-12-ene-28-oic acid and 2$\alpha$. 3$\alpha$. 19$\alpha$ trihydroxyurs-12-ene-28-oic acid (euscaphic acid) exhibiting cytotoxicity and topoisomerase I inhibition. (omitted)

키워드