Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Isolation and Structure Determination of Cytotoxic Compounds with Topoisomerse I and II Inhibitory Activity from the spikes of Prunella vulgaris var. lilaeina

  • Byun, S.J. (College of Pharmacy, Catholic University of Daegu) ;
  • Lee, J.E. (College of Pharmacy, Catholic University of Daeg) ;
  • Son, J.K. (College of Pharmacy, Yeungnam University) ;
  • Lee, J.S. (Department of Biochemistry College of Science, Yeungnam University) ;
  • Lee, S.H. (College of Pharmacy, Yeungnam University) ;
  • Park, Y.S. (College of Pharmacy, Catholic University of Daeg) ;
  • Woo, M.H. (College of Pharmacy, Catholic University of Daegu)
  • Published : 2002.10.01
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Abstract

Prunella vulgaris var. lilacina (Labiatae) has been used as a Korean traditional medicine for the treatment of. fever. inflammation. urinary disadvantage and cancer. We previously isolated three $\alpha$-amyrin triterpenoids from n-butanol-I extract. They are 3$\alpha$-hydroxyurs-12-ene-28-oic acid (ursolic acid). 2$\alpha$, 3$\alpha$-dihydroxyurs-12-ene-28-oic acid and 2$\alpha$. 3$\alpha$. 19$\alpha$ trihydroxyurs-12-ene-28-oic acid (euscaphic acid) exhibiting cytotoxicity and topoisomerase I inhibition. (omitted)

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