대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
- /
- Pages.366.2-366.2
- /
- 2002
SYNTHESIS OF ［1-FLUORO-2.2-BIS-(HYDROXYMETHYL) CYCLOPROPYLMETHYL］ PURINES AS ANTIVIRAL AGENTS
- Park, Ju-Hyun (Sookmyung Women′s University:) ;
- Choi, Myung-Hee (KRIC) ;
- Kim, Hee-Doo (KRIC) ;
-
Lee, Chong-Kyo
(KRICT)
- 발행 : 2002.10.01
초록
In an effort to search for the chemically and enzymatically stable carbonucleoside. we designed ［1'-fluoro-2', 2'-bis-(hydroxymethyl) cyclopropyl methyl］ purines. The underlying concept for our design is to seek relatively conformationally-locked compound with minimal structural disturbance from acyclic carbonucleoside such as acyclovir or penciclovir. To meet such a requirement. we need to introduce cyclopropane and fluorine moiety. (omitted)
키워드