대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.365.2-365.2
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- 2002
SYNTHESIS OF HALOGENATED 9-(DIHYDROXYCYCLOPENT -4′-ENYL) ADENINES AND THEIR INHIBITORY ACTIVITIES AGAINST S-ADENOSYLHOMOCYSTEINE HYDROLASE
- Choi, Won-Jun (College of Pharmacy, Ewha Womans University) ;
- Park, Jae-Gyu (Division of Chemistry and Molecular Engineering. Seoul National University) ;
- Moon, Hyung-Ryong (Division of Chemistry and Molecular Engineering. Seoul National University) ;
- Gunaga Prashantha (Division of Chemistry and Molecular Engineering. Seoul National University) ;
- Lee, Kang-Man (Division of Chemistry and Molecular Engineering. Seoul National University) ;
- Kim, Hea-Ok (Division of Chemistry and Molecular Engineering. Seoul National University) ;
- Jeong, Lak-Shin (Division of Chemistry and Molecular Engineering. Seoul National University)
- 발행 : 2002.10.01
초록
S-Adenosylhomocysteine hydrolase (SAH) catalyzes the hydrolysis of S-adenosylhomocysteine to adenosine and L -homocysteine and has been an attractive target for the development of broad spectrum antiviral agents. Neplanocin A and 9-(dihydroxycyclopent-4' -enyl)adenine (DHCeA) have been known to inhibit SAH by cofactor (NAD＋) depletion mechanism and their inhibition is reversed by the addition of NAD＋ or dialysis. (omitted)
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