대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.363.3-364
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- 2002
Synthesis of 5-Azacytidine Nucleosides With Rigid Sugar Moiety As Potential Antitumor Agents
- Kim, Myong-Jung (College of Pharmacy, Seoul National University) ;
- Lee, Ji-Young (College of Pharmacy, Seoul National University) ;
- Shin, Ji-Hye (College of Pharmacy, Seoul National University) ;
- Chun, Moon-Woo (College of Pharmacy, Seoul National University)
- 발행 : 2002.10.01
초록
Unmodified nucleosides exist in either S-type or N-type conformation, but due to the low energy barrier between this two dominating conformers a fast equilibrium between them exists in solution state. Therefore. many approaches to lock the puckering of the furanose ring in N-type or S-type have been made since HIV-1 reverse transciptase is able to discriminate between two conformationally locked carbocyclic AZT triphosphate analogues. (omitted)
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