대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
- /
- Pages.363.1-363.1
- /
- 2002
Chiral Synthesis of Costunolide
- Sumaila Abu (College of Pharmacy. Kyung Hee Univ.) ;
- Jeong, Jin-Hyun (College of Pharmacy. Kyung Hee Univ) ;
- Shin, Dong-Hyok (College of Pharmacy. Kyung Hee Univ.)
- 발행 : 2002.10.01
초록
Costunolide. a sesquiterpene lactone is isolated from Magnolia Sieboldi. It is known to possess antitumour and anti-inflammatory activities. This compound is synthesized from Ihe easily available decalin dione using the ring cleavage approach to construct the ten-membered ring system. The two keys points in this work are the chiral inductionon the allyl alcohol moiety using Sharpless epoxidation reaction and opening of the eopxide with an organocuprate reagent which leads to a
키워드