대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.362.3-362.3
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- 2002
An Asymmetric Synthesis of (＋)-Polyoxamic acid
- Lee, Ki-Han (College of Pharmacy. Sungkyunkwan University) ;
- Oh, Chang-Young (College of Pharmacy. Sungkyunkwan University) ;
- Lee, Kee-Young (College of Pharmacy. Sungkyunkwan University) ;
- Kim, Yong-Hyun (College of Pharmacy. Sungkyunkwan University) ;
- Lee, Yiu-Suk (College of Pharmacy. Sungkyunkwan University) ;
- Joo, Jae-Eun (College of Pharmacy. Sungkyunkwan University) ;
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Ham, Won-Hun
(College of Pharmacy. Sungkyunkwan University)
- 발행 : 2002.10.01
초록
The Polyoxin complex is an antifungal antibiotics produced by Streptomyces cacaoi var. asoensis that exhibit marked and selective activity against pytopathogenic fungi. They incorporate carbamoylated dipeptides attached to the sugar moiety. Controlled alkaline hydrolysis of polyoxins result in several products. one of which has been identified as (＋)-(2S. 3S, 4S)-2-amino-3. 4. 5-trihydroxypentonic acid(polyoxamic acid). A variety of chemical syntheses of polyoxamic acid have been developed over several years. (omitted)
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