Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.359.3-359.3
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- 2002
Ligand-Based Virtual Screening for inhibitors of PTP-1B with Antihyperglycemic properties
Abstract
Protein-tyrosine phosphatase 1 B(PTP-l B). which plays a key role in insulin signaling. is rising as a fascinating target for type 2 diabetes and obesity. Many scientists in structural biology solved the three dimensional X-ray Crystal structure of this type of enzyme, so we could easily get the active site structure of PTP-1 B or complex structure with ligand. Our virtual screening study for PTP-1B exactly based on these crystal strucutures from public database. (omitted)
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