대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.359.2-359.2
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- 2002
Anti-angiogenic and anti-tumor activity of 2′ -hYdroxy-4′ -methoxychalcone
- Jung, Sang-Hoon (Natural Products Research Institute, Seoul National University) ;
- Lee, Yeon-Sil (Natural Products Research Institute, Seoul National University) ;
- Lee, Sang-Hyun (Natural Products Research Institute, Seoul National University) ;
- Lim, Soon-Sung (Natural Products Research Institute, Seoul National University) ;
- Kim, Yeong-Shik (Natural Products Research Institute, Seoul National University) ;
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Shin, Kuk-Hyun
(Natural Products Research Institute, Seoul National University)
- 발행 : 2002.10.01
초록
In the previous study, we reported that 2'-hydroxy-4'-methxoychalcone, synthetic chalcone inhibited PGE2 production in TPA- stimulated rat peritoneal macrophages by inhibiting the induction of COX-2 protein. The present study was carried out to clarify whether 2'-hydroxy-4'-methoxychalcone inhibit angiogenesis by the experimental methods in vitro and in vivo. 2'-Hydroxy-4'-methoxychalcone decreased angiogenesis of both chick embryos in the chorioallantoic membrane assay and basic fibroblast growth factor-induced vessel formation inthe mouse Martigel plug assay. (omitted)
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