대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.356.3-357
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- 2002
Molecular Dynamics Simulation of Enantioselectivity in Metoprolol in complex
- Jang, Seok-Young (College of Pharmacy. Chungnam National University) ;
- Park, Kyung-Lae (College of Pharmacy. Chungnam National University)
- 발행 : 2002.10.01
초록
Metoprolol (MT) is one kinds of adrenergic beta-blockers. Its (S)-enantiomer is known to be more active than the (R). Recently. the x-ray structure of beta-blocker. (S)-propranolol (a-naphthyl analogue), complexed in a mould fungal cellulase. Cel7A. was reported and the (R)-form did not build any complex. And in our previous study the conformation and stability of MT in carboxymethylated beta-cyclodextrin (BCD) complex was determined by NMR. HPLC, UV and electrophoresis measurement. (omitted)
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