Structural Requirement of Isoflavonones for the Inhibitory Activity of Interleukin-5

  • Cho, Soo-Hyun (College of Pharmacy. Chungnam National University) ;
  • Lee, Jee-Hyun (College of Pharmacy. Chungnam National University) ;
  • Dang, The-Hung (College of Pharmacy. Chungnam National University) ;
  • Ju, Jung-Hun (College of Pharmacy. Chungnam National University) ;
  • Kim, Mi-Kyung (College of Pharmacy. Chungnam National University) ;
  • Lee, Seung-Ho (College of Pharmacy. Chungnam National University) ;
  • Ryu, Jae-Chun (College of Pharmacy. Chungnam National University) ;
  • Kim, Young-Soo (College of Pharmacy. Chungnam National University) ;
  • Jung, Sang-Hun (College of Pharmacy. Chungnam National University)
  • 발행 : 2002.10.01

초록

Interleukin (IL)-5 appears to be one of the main proinflammatory mediators among a growing number of cytokines and chemokines that induce eosinophilic inflammation. Sophoricoside and their analogs isolated from Sophora japonica show relatively potent inhibitory activity of interleukin (IL)-5 as a small molecule. To identify structural requirements of this isoflavonone for its inhibitory activity against IL -5. isoflavonones. isoflavanones, and their glycosides were prepared and tested their inhibitory activity against IL-5. (omitted)

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