대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.354.3-355
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- 2002
Structural Requirement of Isoflavonones for the Inhibitory Activity of Interleukin-5
- Cho, Soo-Hyun (College of Pharmacy. Chungnam National University) ;
- Lee, Jee-Hyun (College of Pharmacy. Chungnam National University) ;
- Dang, The-Hung (College of Pharmacy. Chungnam National University) ;
- Ju, Jung-Hun (College of Pharmacy. Chungnam National University) ;
- Kim, Mi-Kyung (College of Pharmacy. Chungnam National University) ;
- Lee, Seung-Ho (College of Pharmacy. Chungnam National University) ;
- Ryu, Jae-Chun (College of Pharmacy. Chungnam National University) ;
- Kim, Young-Soo (College of Pharmacy. Chungnam National University) ;
- Jung, Sang-Hun (College of Pharmacy. Chungnam National University)
- 발행 : 2002.10.01
초록
Interleukin (IL)-5 appears to be one of the main proinflammatory mediators among a growing number of cytokines and chemokines that induce eosinophilic inflammation. Sophoricoside and their analogs isolated from Sophora japonica show relatively potent inhibitory activity of interleukin (IL)-5 as a small molecule. To identify structural requirements of this isoflavonone for its inhibitory activity against IL -5. isoflavonones. isoflavanones, and their glycosides were prepared and tested their inhibitory activity against IL-5. (omitted)
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