Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
- /
- Pages.353.2-353.2
- /
- 2002
Synthesis and evaluation of antifungal activities of 5-arylamino-6-chloro-4. 7 -dioxoindazoles
- You, Hea-Jung (College of Pharmacy, Ewha Womans University) ;
- Shim, Ju-Yeon (College of Pharmacy, Ewha Womans University) ;
- Shon, Eun-Ha (College of Pharmacy, Ewha Womans University) ;
- Choi, Ko-Un (College of Pharmacy, Ewha Womans University) ;
- Choi, Ik-Hwa (College of Pharmacy, Ewha Womans University) ;
- Chae, Mi-Jin (College of Pharmacy, Ewha Womans University) ;
- Ryu, Chung-Kyu (College of Pharmacy, Ewha Womans University)
- Published : 2002.10.01
Abstract
5-Arylamino-6-chloro-4.7-dioxoindazoles (DZs) were newly synthesized for the evaluation of antifungal activities. The compounds DZs were prepared by regioselective nucleophilic substitution of 5.6-dichloro-4.7-dioxoindazoles with appropriate arylamines in high yield. DZs were tested for their growth inhibitory activities against Candida species and Aspergillus niger. The MIC values were determined by the two-fold dilution method. In general. DZs showed in vitro antifungal activities. Among the tested compounds, DZ1, 3, 6, 7 and 12 showed potent antifungal activities against Candida species and Aspergillus niger. DZ7 was the most effective in preventing the growth of Candida species.
Keywords