Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.350.1-350.1
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- 2002
Diaralkylthiourea Derivatives as a Novel Vanilloid Receptor Antagonist
- Joo, Yung-Hyup (Drug Discovery, Amore Pacific Corporation R＆D Center) ;
- Kim, Jin-Kwan (Drug Discovery, Amore Pacific Corporation R＆D Center) ;
- Kim, Sun-Young (Drug Discovery, Amore Pacific Corporation R＆D Center) ;
- Choi, Jin-Kyu (Drug Discovery, Amore Pacific Corporation R＆D Center) ;
- Koh, Hyun-Ju (Drug Discovery, Amore Pacific Corporation R＆D Center) ;
- Jeong, Yeon-Su (Drug Discovery, Amore Pacific Corporation R＆D Center) ;
- Park, Young-Ho (Drug Discovery, Amore Pacific Corporation R＆D Center) ;
- Chung, Shin (Drug Discovery, Amore Pacific Corporation R＆D Center) ;
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Suh, Young-Ger
(College of Pharmacy, Seoul National University)
;
- Oh, Uh-Taek (College of Pharmacy, Seoul National University) ;
- Park, Hyeung-Geun (College of Pharmacy, Seoul National University) ;
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Kim, Hee-Doo
(College of Pharmacy, Sookmyung Women's University)
- Published : 2002.10.01
Abstract
A series of diaralkylthiourea derivatives was prepared and tested for its antagonistic activity against vanilloid receptor. In this study we explored the possibility of selected compound type (Ⅰ) with tetrahydronaphthyl group as rigid pendant moiety. Our premise for antagonistic activity of molecules was modeled on the capsazepine. the first antagonist for vanilloid receptor. These compounds (Ⅰ) showed less potent antagonistic activity than that of capsazepine. but they were devoid of agonistic activity. (omitted)
Keywords