대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.348.2-348.2
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- 2002
Synthesis of 3-arylisoquinolinamines and 3D-Quantitative Structure Activity Relationships Study
- Min, Sun-Young (College of Pharmacy Chonnam National University) ;
- Cho, Won-Jea (College of Pharmacy Chonnam National University)
- 발행 : 2002.10.01
초록
The significant antitumor activities of 3-arylisoquinolines promoted us to explore the structure-activity relationship of these compounds. A series of 3-Arylisoquinoline derivatives, which related to Benzo［c］ phenanthridine alkaloids. were evaluated for antitumor cytotoxicity against human lung tumor cell (A 549). We tried to study structure-activity relationship (SAR) of 3-Arylisoquinolines using the comparative molecular field analysis (CoMFA) method. (omitted)
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