Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.348.1-348.1
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- 2002
Synthesis and Biological Studies of A Novel Series of Catechol Ether Type Derivatives as Potential Phosphodiesterase(PDE) IV Inhibitors
- Lee, Jae-Mok (Department of Medicinal Chemistry, Cheil Jedang Corp.) ;
- Lee, Koun-Ho (Department of Medicinal Chemistry, Cheil Jedang Corp) ;
- Kim, Jong-Hoon (Department of Medicinal Chemistry, Cheil Jedang Corp) ;
- Song, Seog-Beom (Department of Medicinal Chemistry, Cheil Jedang Corp) ;
- Chun, Hyung-Ok (Department of Medicinal Chemistry, Cheil Jedang Corp) ;
- Yeon, Kyu-Jeong (Department of Medicinal Chemistry, Cheil Jedang Corp) ;
- Kwon, Soon-Ji (Department of Medicinal Chemistry, Cheil Jedang Corp.)
- Published : 2002.10.01
Abstract
We synthesized various catechol ether type derivatives substituted by the hydrazine moiety and evaluated for their ability to inhibit PDE Ⅳ (Phosphodiesterase Ⅳ). These new compounds were synthesized from 4-methoxy-3-hydroxy benzaldehyde through 5 or 7 steps. Some of them have similar or more potent inhibitory activity against PDE Ⅳ than known PDE Ⅳ inhibitor. Ariflo (SB 207499). Structure activity relationship (SAR) and biological studies of described compounds will be discussed in detail. (omitted)
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