Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.347.2-347.2
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- 2002
Diasteroselective synthesis of long chained keto amino acids derivatives
- Kim, Eun-Young (Natural Products Research Institute, Seoul National University) ;
- Kim, Eun-Jung (Natural Products Research Institute, Seoul National University) ;
- Ko, Hyo-Jin (Natural Products Research Institute, Seoul National University)
- Published : 2002.10.01
Abstract
The unusal keto amino acid. (s)-2-amino-8-oxodecanoic acid(Aoda) is a biologically important constituent of the naturally occurring cyclic tetrapeptides such as apicidins. Consequently extensive chemical modifications of Aoda residue of apicidin were studied, and we are obtained the practical and versatile synthesis of the long-chained keto amino acids in enantlomerically pure form by alkylation with bromoketone and chiral Scholkopf auxiilary. (omitted)
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