대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.344.3-345
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- 2002
Revisit to Unfulfilled Premise of Arylsulfonylimidazolidinones as Anticancer Agent
- Hung, Dang-The (College of Pharmacy, Chungnam National University) ;
- Lee, Jee-Hyun (College of Pharmacy, Chungnam National University) ;
- Cho, Soo-Hyun (College of Pharmacy, Chungnam National University) ;
- Hong, Chang-Yong (College of Pharmacy, Chungnam National University) ;
- Jeong, Shin-Wu (College of Pharmacy, Chungnam National University) ;
- Jeon , Ki-Wan (College of Pharmacy, Chungnam National University) ;
- Lee, Sung-Bae (College of Pharmacy, Chungnam National University) ;
- Choi, Whan-Geun (College of Pharmacy, Chungnam National University) ;
- Jung, Sang-Hun (College of Pharmacy, Chungnam National University)
- 발행 : 2002.10.01
초록
For the development of novel anticancer agent. we have designed. synthesized. and tested novel 4-phenyl-1(N)-arylsulfonylimidazolidinones. As a result. much more potent cytotoxicities of these compounds against the various cancer cell lines than those of doxorubicin were demonstrated. Elaboration on aryl motif on sulfonyl moiety led us to find highly potent 4-phenyl-1-(N-acylindoline-5-sulfonyl)imidazolidinones. Among them, 4-phenyl-l- [N-(p-aminobenzoyl)indoline-5-sulfonyl]imidazolidinone (PA) was proved to have good pharmacological profile. (omitted)
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