대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.340.1-340.1
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- 2002
Structure-Activity Relationship Study of Asiatic Acid Derivatives for New Wound Healing Agent
- Jew, Sang-Sup (Seoul National University) ;
- Lim, Doo-Yeon (Seoul National University) ;
- Park, Sun-Young (Seoul National University) ;
- Suh, Sung-Ki (Seoul National University) ;
- Nam, Tae-Kyu (Seoul National University) ;
- Kim, So-Yeon (Sookmyung Womans University) ;
- Kim, Dong-Sun (Dong Kook Phar) ;
- Cha, Kyung-Hoe (Dong Kook Phar) ;
- Park, Eun-Hee (Sookmyung Womans University) ;
- Son, Dong-Whan (Wonkwang University) ;
- Kim, Sang-Gun (Seoul National University) ;
- Park, Hyeung-Geun (Seoul National University)
- 발행 : 2002.10.01
초록
Centella asiatica is an herbal plant used on different continents by diverse ancient cultures and tribal groups. Historically. the extract has been used as a wound healing agent, The extract has three different triterpenoid ingredients: asiaticoside. asiatic acid, and madecassic acid. It has been reported that its wound healing activity is associated with the modulation of collagen synthesis in the skin dermis. The wound healing property of the extract has led to its commercial introduction under the trade name, Madecrlssol. As part of our program toward the development of new wound healing agents. structere activity relationship (SAR) studies have been performed by modifying asiatic acid. In this communication. the SAR study of esiatic acid for the development of an efficient woind healing agent is reported.
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