대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
- /
- Pages.328.1-328.1
- /
- 2002
cDNA cloning of a membrane-associated. magnesium-dependent 30kDa neutral sphingomyelinase
- Jeon, Hyung-Jun (Department of Health and Environmental Chemistry, College of Pharmacy, Chung-Ang University) ;
- Jung, Sung-Yun (Department of Health and Environmental Chemistry, College of Pharmacy, Chung-Ang University) ;
- Kim, Dae-Kyong (Department of Health and Environmental Chemistry, College of Pharmacy, Chung-Ang University)
- 발행 : 2002.10.01
초록
A major lipid-signaling pathway in mammalian cells implicated the activation of sphingomyelinase (SMase), which hydrolyses sphingomyeline to generate ceramide and phosphocholine. Sphingomyelinase is divided into many isoform groups dependent on optimal pH, and essential cation especially magnesium in their activation. Such as acidic sphingomyelinase, neutral sphingomyelinase and alkaline sphingomyelinase. Ceramide is known as a crucial second messenger in cell responses like cell proliferation. cell cycle arrest. cellular senescence, and apoptosis. (omitted)
키워드