Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Autotaxin-induced tumor cell motility requires the activation of Rac/Cdc42. PAK, and FAK

  • Jung, In-Duk (Department of Pharmacology. College of Medicine, Konyang University) ;
  • Lee, Jang-Soon (Department of Pharmacology. College of Medicine, Konyang University) ;
  • Young, Yun-Seong (Department of Pharmacology. College of Medicine, Konyang University) ;
  • Park, Chang-Gyo (Department of Pharmacology. College of Medicine, Konyang University) ;
  • Lee, Hoi-Young (Department of Pharmacology. College of Medicine, Konyang University)
  • Published : 2002.10.01
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Abstract

Cell motility plays important physiological roles in embryogenesis. immune defense. wound healing. and metastasis of tumor cells. Cell motility of normal cells is tightly regulated. while tumor cell motility is aberrantly regulated or autoregulated. Autotaxin (ATX) is a 125-kDa glycoprotein. originally isolated from the conditioned medium of human melanoma A2058 cells. ATX stimulates random (chemokinetic) and directed (chemotactic) motility of human tumor cells at high picomolar to low nanomolar concentrations. (omitted)

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