Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.322.3-323
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- 2002
Curcumin Inhibits Phorbol Ester-induced Expression of Cyclooxygenase-2 In Vivo through Suppression of Extracelluar Signal-regulated Kinase (ERK) 1/2 and NF-${\kappa}$ /B in Mouse Skin
- Chun, Kyung-Soo (College of Pharmacy. Seoul National University) ;
- Surh, Young-Joon (College of Pharmacy. Seoul National University)
- Published : 2002.10.01
Abstract
Curcumin derived from turmeric (Curcuma longa L.. Zingiberaceae) has been shown to possess marked chemopreventive activities, but the underlying molecular mechanisms remain unclear. In the present work. curcumin was found to inhibit 12-Ο-tetradecanoylphorbol-13-acetate(TPA)-induced expression of cyclooxygenase-2 (COX-2) in female ICr mouse skin as determined by Western and Northern blot analysis as well as immunohistochemical staining. Curcumin treatment atlenuated TPA-stimulated epidermal NF-
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