대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.322.1-322.1
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- 2002
Tyrosine kinase inhibitors reverse lawsone methyl ether stimulation of renal dipeptidase release but not of alkaline phosphatase release.
- Park, Eun-Mi (Department of Pharmacy, College of Pharmacy, Chonnam National University) ;
-
Yoon, Hyun-Joong
(Department of Pharmacy, College of Pharmacy, Chonnam National University)
;
- Park, Haeng-Soon (Department of Pharmacy, College of Pharmacy, Chonnam National University)
- 발행 : 2002.10.01
초록
Lawsone methyl ether (LME. 2-methoxy-1, 4-naphthoquinone) is a natural compound found in balsaminaceae. In this study the effect of LME on the release of renal dipeptidase (RDPase) and alkaline phosphatase (APase) known as glycosylphosphatidylinositol (GPI) anchored proteins was examined from the renal proximal tubules. Compared with control, LME (0.5mM) increased RDPase release (218%) and APase release (135%). The increase of RDPase release by LME showed concentration-dependent effect but the release pattern of APase did not. (omitted)
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