Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Isolation. structure. and NF-${\kappa}$B modulatory activity of Harzianum A and B: trichothecene from fungi(B000527)

  • Jin, Hui-Zi (Anticancer Agents Research Laboratory, Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Jeong-Hyung (Anticancer Agents Research Laboratory, Korea Research Institute of Bioscience and Biotechnolog) ;
  • Kim, Young-Ho (College of Pharmacy. Chungnam National University) ;
  • Lee, Jung-Joon (Anticancer Agents Research Laboratory, Korea Research Institute of Bioscience and Biotechnology)
  • Published : 2002.10.01
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Abstract

Nuclear factor ${\kappa}$B (NF-${\kappa}$B) represents a family of eukaryotic transcription factors participating in the regulation of various cellular genes. Since aberrant regulation of NF-${\kappa}$B has been implicated in the pathogenesis of various diseases including inflammation. asthma. atherosclerosis. AIDS. septic shock. arthritis, and cancer. this transcription factor has been shown to be an interesting target of new drug discovery. (omitted)

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